The intestinal permeability test (or Leaky Gut Test as it’s commonly known) assesses your intestinal lining. When the at Gastrointestinal tract is not functioning correctly, toxins are absorbed (leaked) into the bloodstream. The control and quality of intestinal permeability can be affected throughout your life by changes in our health and due to many other factors including medication, toxins parasites, bacteria, allergies, poor diet, food sensitivities and autoimmune disorders.

There are many symptoms of intestinal permeability, the most common are: bloating, candida overgrowth, constipation, diarrhea, gas. Other signals can be brain fog, skin rashes, nutritional deficiencies (from poor absorption). The symptoms may be mild or severe. If you’re experiencing any of these symptoms contact our Prahran diagnostic testing team for an assessment.

Test Method

The leaky gut test involves drinking a sugar solution and providing a urine sample that is used to assess the quality and effectiveness of your digestive absorption. If levels of these sugars are found in the urine it indicates that they have passed through your intestinal walls and into your bloodstream. The amount of sugar found in the blood provides an indication of the  leaky gut condition and severity.

The test works on the principle that small molecules are readily absorbed by the intestinal villi, whilst larger molecules such as disaccharides are not. These water soluble non-metabolised sugar molecules after penetrating the intestinal tract are excreted into the urine.  Under normal circumstances the ratio of the molecules in urine is low When the structure of the intestinal epithelium is jeopardised (‘leaky gut’ is present), the large sugar molecule can permeate the mucosa and is recovered in the urine.  In this situation the levels are increased in the urine and therefore the ratio is high.  Furthermore, the intestinal permeability test Melbourne has been used to monitor the compliance and effectiveness of a gluten-free diet in patients with Coeliac disease.

In addition to assessing leaky gut, this test can also help diagnose malabsorption.  If a low level of mannitol which normally penetrates the intestinal epithelium is observed, it may indicate malabsorption of small molecules and possible atrophy of the intestinal villi.




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